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| CAS:501019‑16‑5:Delmitide acetate | |
| Delmitide is a structurally optimized intestinal anti‑inflammatory peptide. It inhibits excessive secretion of key pro‑inflammatory cytokines such as TNF‑ , IL‑1 and IL‑12 in the intestinal mucosa, downregulates the inflammatory cascade, while promoting the expression of mucosal repair factors, alleviating inflammatory damage and ulcer formation of intestinal mucosa, and improving intestinal barrier function. It has mild effect, mainly local mucosal anti‑inflammation, without systemic immunosuppressive side effects of broad‑spectrum immunosuppressants. Applied in mechanism research of inflammatory bowel disease, ulcerative colitis and other diseases, as well as anti‑inflammatory peptide drug development. | |
| 95%/98%/99% | |
| ~1200 (subject to actual synthetic batch) | |
| Function Tags (comma-separated) | ||||||||
| Mucosal anti-inflammation, Pro-inflammatory cytokine inhibition, Inflammatory bowel disease, Intestinal barrier repair, Immunomodulation, Anti-inflammatory peptide | Linear synthetic peptide backbone with optimized anti-inflammatory activity and mucosal affinity | - | ~1200 (theoretical) | ~10 |
| Long-term Storage | Short-term Storage | ||||
| PEP-DEL001 | Store at -20℃, sealed, dry & protected from light, aliquoted; avoid repeated freeze-thaw cycles | Stable for 2 weeks at 2-8℃ sealed & dry; ice pack shipping recommended | Stable for 72h at 4℃ under sterile conditions; easily degraded and inactivated by intestinal proteases at room temperature**Good water solubility, freely soluble in water and neutral physiological buffer**. Native linear peptide easily degraded by proteases | Stable for 2 years at -20℃ under dry & dark conditions |
| Applicable Research Areas (comma-separated) | ||||
| PEP-DEL001 | Intestinal-targeted anti-inflammatory peptide that inhibits pro-inflammatory cytokine release, alleviates mucosal inflammation and promotes barrier repair | Delmitide acts on immune cells and epithelial cells of the intestinal mucosa, regulates core inflammatory signaling pathways such as NF-κB and MAPK, inhibits excessive activation of macrophages and T cells, reduces the secretion of pro-inflammatory cytokines such as TNF- , IL-1 , IL-12 and IFN- , downregulates the inflammatory cascade of the intestinal mucosa, and alleviates tissue edema, ulcer and inflammatory infiltration; meanwhile, it promotes tight junction protein expression and epithelial cell proliferation, repairs the damaged intestinal mucosal barrier, and improves intestinal permeability. Different from glucocorticoids and broad-spectrum immunosuppressants, its anti-inflammatory effect is mild and targets the intestinal local area, does not cause systemic immune function suppression, with lower infection risk. | Inflammatory bowel disease research, Ulcerative colitis, Intestinal barrier function, Mucosal immune regulation, Chronic intestinal inflammation, Anti-inflammatory peptide development | NF-κB/MAPK inflammatory signaling pathway; Pro-inflammatory cytokine secretion inhibitory pathway; Intestinal mucosal barrier repair pathway |
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